• Design
• Chief/Principal investigators
• Co-investigators
• Status
• Unit role
• Sponsors
• Funding
• Data sharing

Design

Research outcomes

The primary endpoint at ten year follow up is the modelled 10-year risk of cardiovascular disease

Secondary endpoints at ten year follow up include:

1. Time to first event of composite CVD endpoint. This compromises of CVD mortality, CVD morbidity (non-fatal stroke, non-fatal myocardial infarction, all revascularisations, amputations (except for traumatic)).
2. All cause mortality.
3. Changes in biochemical outcomes including HbA1c levels, total, HDL & LDL cholesterol and triglycerides collected through medical records.
4. Microvascular endpoints: Neuropathy measured by the Michigan neuropathy questionnaire; Renal function through Albumin Creatinine ratio (ACR) & estimated glomerular filtration rate (eGFR) blood results; and development of eye complications through assessment of latest retinal image and eye examination.
5. Most recent clinical height and weight measures and blood pressure readings from medical records.
6. Other health status outcomes such as smoking status, alcohol consumption, physical activity (IPAQ) through self report questionnaire.
7. Functional status (SF36); health utility (EQ5D); quality of life and well being measures specific to diabetes (AddQoL & DTS); and health service use and prescribed medication(Adapted Aberdeen HSRU).
8. Quality of GP/Nurse therapeutic relationship using an approved adapted version of the CARE measure.
9. Diet, using a FFQ previously delivered at 5 year follow up.
10. Additional physical activity data using EPAQ2.

A detailed explanation of the study can be found here, and one-year study results are published here.

Chief/Principal investigator

Professor Simon Griffin – University of Cambridge

Co-Investigators

Professor Nick Wareham – University of Cambridge

Professor Ann Louise Kinmonth – University of Cambridge

Stephen Sutton – University of Cambridge

Status

Field work completed.

Unit role

Unit led study with responsibility for data.

Sponsors

The study is sponsored by the University of Cambridge.

Funding

Unit involvement in ADDITION is funded by MRC core funding, plus grant support: Wellcome Trust (grant reference no: G061895), the Medical Research Council (grant reference no: G0001164), the NIHR Health Technology Assessment Programme (grant reference no: 08/116/300), National Health Service R&D support funding (including the Primary Care Research and Diabetes Research Networks) and the National Institute for Health Research [RP-PG-0606-1259].

Data sharing

Please see our Data Sharing portal.