Honorary Senior Visiting Fellow

Aetiology and Mechanisms of Diabetes and Related Metabolic Disorders of Later Life

Current work and interests

• Viral Infections.
• Chronic Infections and their associations with the host.
• Epidemiology of Hospital infections.
• Emerging Infectious Diseases.
• Medical Education.

As an Infectious Diseases consultant she has specific expertise in treating patients with primary and secondary immunodeficiencies, recurrent infections as well as travel related illness and complex HIV.

http://www.infectiousdisease.cam.ac.uk/

Background and experience

Qualified in Medicine in Athens, Greece and trained in Internal Medicine and Infectious Diseases in Philadelphia and Chicago, USA. Completed Master’s in Public Health in UIC in Chicago, USA. ABIM certified in Infectious Diseases (2004-14) and Internal Medicine (2002-2012 and 2012-2022). Appointed Consultant in Infectious Diseases in September 2005 at Addenbrooke’s NHS Foundation Trust, Cambridge, UK. Appointed Clinical Director in Infectious Diseases in October 2008. Completed PhD in Epidemiology in the Medical Research Council Epidemiology Unit in the University of Cambridge in October 2012.

Publications

Selected publications

• Cottle LE, Gkrania-Klotsas E, Williams HJ, Brindle HE, Carmichael AJ, Fry G, Beeching NJ. A multinational outbreak of histoplasmosis following a biology field trip in the ugandan rainforest. J Travel Med. 2013 Mar;20(2):83-7. doi:10.1111/jtm.12012. Epub 2013 Jan 30. PubMed PMID: 23464714.
• Gkrania-Klotsas E, Langenberg C, Sharp SJ, Luben R, Khaw KT, Wareham NJ.
  Seropositivity and higher IgG antibody levels against Cytomegalovirus are associated with mortality in the population based EPIC-Norfolk cohort. Clin Infect Dis. 2013 Feb 26. [Epub ahead of print] PubMed PMID: 23442763.
• Bloomfield MG, Carmichael AJ, Gkrania-Klotsas E. Mortality in Clostridium difficile infection: a prospective analysis of risk predictors. Eur J Gastroenterol Hepatol. 2013 Feb 24. [Epub ahead of print] PubMed PMID: 23442414.
• Lim PL, Han P, Chen LH, MacDonald S, Pandey P, Hale D, Schlagenhauf P, Loutan L, Wilder-Smith A, Davis XM, Freedman DO; GeoSentinel Surveillance Network. Expatriates ill after travel: results from the Geosentinel Surveillance Network. BMC Infect Dis. 2012 Dec 31;12:386. doi: 10.1186/1471-2334-12-386. PubMed PMID: 23273048.
• Gkrania-Klotsas E, Langenberg C, Sharp SJ, Luben R, Khaw KT, Wareham NJ.
  Higher immunoglobulin G antibody levels against cytomegalovirus are associated with incident ischemic heart disease in the population-based EPIC-Norfolk cohort. J Infect Dis. 2012 Dec 15;206(12):1897-903. doi: 10.1093/infdis/jis620. Epub 2012 Oct 8. PubMed PMID: 23045624.
• Gautret P, Cramer JP, Field V, Caumes E, Jensenius M, Gkrania-Klotsas E, de Vries PJ, Grobusch MP, Lopez-Velez R, Castelli F, Schlagenhauf P, Hervius Askling H, von Sonnenburg F, Lalloo DG, Loutan L, Rapp C, Basto F, Santos O’Connor F, Weld L, Parola P; EuroTravNet Network. Infectious diseases among travellers and migrants in Europe, EuroTravNet 2010. Euro Surveill. 2012 Jun 28;17(26). doi:pii: 20205. PubMed PMID: 22790534.
• Bloomfield MG, Sherwin JC, Gkrania-Klotsas E. Risk factors for mortality in Clostridium difficile infection in the general hospital population: a systematic review. J Hosp Infect. 2012 Sep;82(1):1-12. doi: 10.1016/j.jhin.2012.05.008. Epub 2012 Jun 22. Review. PubMed PMID: 22727824.
• Esposito DH, Han PV, Kozarsky PE, Walker PF, Gkrania-Klotsas E, Barnett ED, Libman M, McCarthy AE, Field V, Connor BA, Schwartz E, MacDonald S, Sotir MJ; GeoSentinel Surveillance Network. Characteristics and spectrum of disease among ill returned travelers from pre- and post-earthquake Haiti: The GeoSentinel experience. Am J Trop Med Hyg. 2012 Jan;86(1):23-8. doi: 10.4269/ajtmh.2012.11-0430. PubMed PMID: 22232445; PubMed Central PMCID: PMC3247103.
• Gkrania-Klotsas E, Langenberg C, Tauriainen S, Sharp SJ, Luben R, Forouhi NG, Khaw KT, Hyöty H, Wareham NJ. The association between prior infection with five serotypes of Coxsackievirus B and incident type 2 diabetes mellitus in the EPIC-Norfolk study. Diabetologia. 2012 Apr;55(4):967-70. doi:10.1007/s00125-011-2443-7. Epub 2012 Jan 10. PubMed PMID: 22231126.
• Wills M, Akbar A, Beswick M, Bosch JA, Caruso C, Colonna-Romano G, Dutta A, Franceschi C, Fulop T, Gkrania-Klotsas E, Goronzy J, Griffiths SJ, Henson S, Herndler-Brandstetter D, Hill A, Kern F, Klenerman P, Macallan D, Macualay R, Maier AB, Mason G, Melzer D, Morgan M, Moss P, Nikolich-Zugich J, Pachnio A, Riddell N, Roberts R, Sansoni P, Sauce D, Sinclair J, Solana R, Strindhall J, Trzonkowski P, van Lier R, Vescovini R, Wang G, Westendorp R, Pawelec G. Report from the second cytomegalovirus and immunosenescence workshop. Immun Ageing. 2011 Oct 28;8(1):10. doi: 10.1186/1742-4933-8-10. PubMed PMID: 22035114; PubMed Central PMCID: PMC3222598.
• Odolini S, Parola P, Gkrania-Klotsas E, Caumes E, Schlagenhauf P, López-Vélez R, Burchard GD, Santos-O’Connor F, Weld L, von Sonnenburg F, Field V, de Vries P, Jensenius M, Loutan L, Castelli F. Travel-related imported infections in Europe, EuroTravNet 2009. Clin Microbiol Infect. 2012 May;18(5):468-74. doi:10.1111/j.1469-0691.2011.03596.x. Epub 2011 Aug 16. PubMed PMID: 21848975.
• Flores-Figueroa J, Okhuysen PC, von Sonnenburg F, DuPont HL, Libman MD, Keystone JS, Hale DC, Burchard G, Han PV, Wilder-Smith A, Freedman DO; GeoSentinel Surveillance Network. Patterns of illness in travelers visiting Mexico and Central America: the GeoSentinel experience. Clin Infect Dis. 2011 Sep;53(6):523-31. doi: 10.1093/cid/cir468. Epub 2011 Aug 10. PubMed PMID: 21832261.
• Molloy A, Matheson NJ, Meyer PA, Chaterjee K, Gkrania-Klotsas E. Cushing’s syndrome and adrenal axis suppression in a patient treated with ritonavir and corticosteroid eye drops. AIDS. 2011 Jun 19;25(10):1337-9. doi:10.1097/QAD.0b013e328347c09c. PubMed PMID: 21659797.
• Thwaites GE, Edgeworth JD, Gkrania-Klotsas E, Kirby A, Tilley R, Török ME, Walker S, Wertheim HF, Wilson P, Llewelyn MJ; UK Clinical Infection Research Group. Clinical management of Staphylococcus aureus bacteraemia. Lancet Infect Dis. 2011 Mar;11(3):208-22. doi: 10.1016/S1473-3099(10)70285-1. Review. PubMed PMID: 21371655.
• Thwaites GE; United Kingdom Clinical Infection Research Group (UKCIRG). The management of Staphylococcus aureus bacteremia in the United Kingdom and Vietnam: a multi-centre evaluation. PLoS One. 2010 Dec 13;5(12):e14170. doi:10.1371/journal.pone.0014170. PubMed PMID: 21179193; PubMed Central PMCID: PMC3001442.
• Field V, Gautret P, Schlagenhauf P, Burchard GD, Caumes E, Jensenius M, Castelli F, Gkrania-Klotsas E, Weld L, Lopez-Velez R, de Vries P, von Sonnenburg F, Loutan L, Parola P; EuroTravNet network. Travel and migration associated infectious diseases morbidity in Europe, 2008. BMC Infect Dis. 2010 Nov 17;10:330. doi: 10.1186/1471-2334-10-330. PubMed PMID: 21083874; PubMed Central PMCID: PMC3001727.
• Gkrania-Klotsas E, Ye Z, Cooper AJ, Sharp SJ, Luben R, Biggs ML, Chen LK, Gokulakrishnan K, Hanefeld M, Ingelsson E, Lai WA, Lin SY, Lind L, Lohsoonthorn V, Mohan V, Muscari A, Nilsson G, Ohrvik J, Chao Qiang J, Jenny NS, Tamakoshi K, Temelkova-Kurktschiev T, Wang YY, Yajnik CS, Zoli M, Khaw KT, Forouhi NG, Wareham NJ, Langenberg C. Differential white blood cell count and type 2 diabetes: systematic review and meta-analysis of cross-sectional and prospective studies. PLoS One. 2010 Oct 18;5(10):e13405. doi: 10.1371/journal.pone.0013405. PubMed PMID: 20976133; PubMed Central PMCID: PMC2956635.
• Boggild AK, Castelli F, Gautret P, Torresi J, von Sonnenburg F, Barnett ED, Greenaway CA, Lim PL, Schwartz E, Wilder-Smith A, Wilson ME; GeoSentinel Surveillance Network. Vaccine preventable diseases in returned international travelers: results from the GeoSentinel Surveillance Network. Vaccine. 2010 Oct 28;28(46):7389-95. doi: 10.1016/j.vaccine.2010.09.009. Epub 2010 Sep 17. PubMed PMID: 20851081.
• Mendelson M, Davis XM, Jensenius M, Keystone JS, von Sonnenburg F, Hale DC, Burchard GD, Field V, Vincent P, Freedman DO; GeoSentinel Surveillance Network. Health risks in travelers to South Africa: the GeoSentinel experience and implications for the 2010 FIFA World Cup. Am J Trop Med Hyg. 2010 Jun;82(6):991-5. doi: 10.4269/ajtmh.2010.10-0198. PubMed PMID: 20519590.
• Parks T, Gkrania-Klotsas E, Nicholl C. Treatment with monoclonal antibodies against Clostridium difficile toxins. N Engl J Med. 2010 Apr 15;362(15):1444; author reply 1445-6. doi: 10.1056/NEJMc1002213. PubMed PMID: 20393181.
• Hagmann S, Neugebauer R, Schwartz E, Perret C, Castelli F, Barnett ED, Stauffer WM; GeoSentinel Surveillance Network. Illness in children after international travel: analysis from the GeoSentinel Surveillance Network. Pediatrics. 2010 May;125(5):e1072-80. doi: 10.1542/peds.2009-1951. Epub 2010 Apr 5. PubMed PMID: 20368323.
• Schlagenhauf P, Chen LH, Wilson ME, Freedman DO, Tcheng D, Schwartz E, Pandey P, Weber R, Nadal D, Berger C, von Sonnenburg F, Keystone J, Leder K; GeoSentinel Surveillance Network. Sex and gender differences in travel-associated disease. Clin Infect Dis. 2010 Mar 15;50(6):826-32. doi: 10.1086/650575. PubMed PMID:20156059.
• Parks T, Wallis S, Wilson J, Gkrania-Klotsas E, Nicholl C. Continuing diarrhoea after ten days of oral metronidazole or oral vancomycin for presumed, hospital-acquired Clostridium difficile colitis in elderly hospital patients. J Hosp Infect. 2010 Apr;74(4):403-5. doi: 10.1016/j.jhin.2009.11.002. Epub 2010 Feb 12. PubMed PMID: 20153080.
• Cooke FJ, Gkrania-Klotsas E. Clostridium difficile infection: more known than is realised. Ann R Coll Surg Engl. 2010 Jan;92(1):89; author reply 89-90. doi:10.1308/003588410X12518836439849. PubMed PMID: 20056074.
• Cooke FJ, Gkrania-Klotsas E, Howard JC, Stone M, Kearns AM, Ganner M, Carmichael AJ, Brown NM. Clinical, molecular and epidemiological description of a cluster of community-associated methicillin-resistant Staphylococcus aureus isolates from injecting drug users with bacteraemia. Clin Microbiol Infect. 2010 Jul;16(7):921-6. doi: 10.1111/j.1469-0691.2009.02969.x. Epub 2009 Nov 11. PubMed PMID: 19912266.
• Jensenius M, Davis X, von Sonnenburg F, Schwartz E, Keystone JS, Leder K, Lopéz-Véléz R, Caumes E, Cramer JP, Chen L, Parola P; GeoSentinel Surveillance Network. Multicenter GeoSentinel analysis of rickettsial diseases in international travelers, 1996-2008. Emerg Infect Dis. 2009 Nov;15(11):1791-8. doi: 10.3201/eid1511.090677. PubMed PMID: 19891867.
• Gautret P, Schlagenhauf P, Gaudart J, Castelli F, Brouqui P, von Sonnenburg F, Loutan L, Parola P; GeoSentinel Surveillance Network. Multicenter EuroTravNet/GeoSentinel study of travel-related infectious diseases in Europe. Emerg Infect Dis. 2009 Nov;15(11):1783-90. doi: 10.3201/eid1511.091147. PubMed PMID: 19891866.
• Chen LH, Wilson ME, Davis X, Loutan L, Schwartz E, Keystone J, Hale D, Lim PL, McCarthy A, Gkrania-Klotsas E, Schlagenhauf P; GeoSentinel Surveillance Network. Illness in long-term travelers visiting GeoSentinel clinics. Emerg Infect Dis. 2009 Nov;15(11):1773-82. doi: 10.3201/eid1511.090945. PubMed PMID:19891865.
• Pollock E, Klotsas AE, Compston J, Gkrania-Klotsas E. Bone health in HIV infection. Br Med Bull. 2009;92:123-33. doi: 10.1093/bmb/ldp037. Epub . Review. PubMed PMID: 19875393.
• Tsagkaraki AP, Sampaziotis F, Cooke FJ, Gkrania-Klotsas E. Assessing staff knowledge about Clostridium difficile diarrhoea. J Hosp Infect. 2009 May;72(1):81-3. doi: 10.1016/j.jhin.2009.02.006. Epub 2009 Mar 12. PubMed PMID:19282050.
• Gkrania-Klotsas E, Cooke FJ, Zochios V, Lofitou N. Fever, a blue hand, and abducens nerve paralysis in a returning traveler. J Travel Med. 2009 Jan-Feb;16(1):57-9. doi: 10.1111/j.1708-8305.2008.00262.x. PubMed PMID: 19192131.
• Connick RM, Connick P, Klotsas AE, Tsagkaraki PA, Gkrania-Klotsas E. Procedural confidence in hospital based practitioners: implications for the training and practice of doctors at all grades. BMC Med Educ. 2009 Jan 12;9:2. doi: 10.1186/1472-6920-9-2. PubMed PMID: 19138395.
• Weekes M, Matheson N, Coggle S, Gkrania-Klotsas E. Furuncular myiasis. BMJ Case Rep. 2009;2009. doi:pii: bcr06.2009.2026. 10.1136/bcr.06.2009.2026. Epub 2009 Aug 25. PubMed PMID: 21866234.
• Gkrania-Klotsas E, Lever AM. Herpes simplex I encephalitis presenting as a brain haemorrhage with normal cerebrospinal fluid analysis: a case report. J Med Case Rep. 2008 Dec 17;2:387. doi: 10.1186/1752-1947-2-387. PubMed PMID: 19091062.
• Nicolls DJ, Weld LH, Schwartz E, Reed C, von Sonnenburg F, Freedman DO, Kozarsky PE; GeoSentinel Surveillance Network. Characteristics of schistosomiasis in travelers reported to the GeoSentinel Surveillance Network 1997-2008. Am J Trop Med Hyg. 2008 Nov;79(5):729-34. PubMed PMID: 18981513.
• Gkrania-Klotsas E, Klotsas AE. HIV and HIV treatment: effects on fats, glucose and lipids. Br Med Bull. 2007;84:49-68. Epub 2007 Nov 2. Review. PubMed PMID: 17981955.
• Gkrania-Klotsas E, Hershow RC. Colonization or infection with multidrug-resistant Acinetobacter baumannii may be an independent risk factor for increased mortality. Clin Infect Dis. 2006 Nov 1;43(9):1224-5. PubMed PMID:17029151.
• Gkrania-Klotsas E, Lever AM. An update on malaria prevention, diagnosis and treatment for the returning traveller. Blood Rev. 2007 Mar;21(2):73-87. Epub 2006 Jul 3. Review. PubMed PMID: 16815604.
• Gkrania-Klotsas E, Lever AM. A husband and wife with left hand rashes. Lancet Infect Dis. 2005 Dec;5(12):802. PubMed PMID: 16310152.